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Specific components of personal skin care products such as lavender necessary oil or tea tree oil and specific dietary supplements such as dong quai and have been related to gynecomastia. Persistent disease [modify] People with kidney failure are often malnourished, which might add to gynecomastia development. Dialysis might attenuate poor nutrition of kidney failure.

In people with liver failure or cirrhosis, the liver's capability to correctly metabolize hormones such as estrogen may be impaired. Furthermore, those with alcoholic liver disease are even more jeopardized for advancement of gynecomastia; ethanol might directly interrupt the synthesis of testosterone and the existence of phytoestrogens in alcoholic beverages may likewise add to a higher estrogen to testosterone ratio.

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A small percentage of male gynecomastia cases may be seen with rare inherited disorders such as back and bulbar muscular atrophy and the very unusual aromatase excess syndrome. Testicular tumors such as Leydig cell growths or Sertoli cell tumors (such as in Peutz, Jeghers syndrome) or h, CG-producing choriocarcinoma may result in gynecomastia.

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Individuals with prostate cancer who are treated with androgen deprivation treatment might experience gynecomastia. Pathophysiology [edit] Pathology: A big glandular mass of male breast tissue, surgically got rid of The causes of common gynecomastia remain uncertain, however are believed to result from an imbalance between the actions of estrogen and androgens at the breast tissue.

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As in women, estrogen promotes the growth of breast tissue in males. In addition to directly stimulating male breast tissue growth, estrogens indirectly decrease secretion of testosterone by reducing luteinizing hormone secretion, resulting in reduced testicular secretion of testosterone. Furthermore, estrogens can increase blood levels of the protein sex hormone-binding globulin (SHBG), which binds free testosterone (the active form) leading to reduced action of testosterone in male breast tissue.

Klinefelter syndrome is a significant example of a disorder that causes hypogonadism and gynecomastia, and has a greater danger of breast cancer in males (2050 times higher than males without the disorder). Central hypogonadism (indicating an issue with the brain) leads to decreased production and release of luteinizing hormonal agent (LH, a stimulatory signal for endogenous steroid hormonal agent synthesis) which results in reduced production of testosterone and estradiol in the testes.